Manual of Molecular and Clinical Laboratory Immunology

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Bibliografische Daten
ISBN/EAN: 9781683673262
Sprache: Englisch
Umfang: 46.67 MB
Auflage: 8. Auflage 2016
Format: EPUB
DRM: Adobe DRM


<p><b>THE authoritative guide for clinical laboratory immunology</b></p><p>For over 40 years the<i>Manual of Molecular and Clinical Laboratory Immunology</i> has served as the premier guide for the clinical immunology laboratory. From basic serology testing to the present wide range of molecular analyses, the<i>Manual</i> has reflected the exponential growth in the field of immunology over the past decades. This eighth edition reflects the latest advances and developments in the diagnosis and treatment of patients with infectious and immune-mediated disorders.</p> The<i>Manual</i> features detailed descriptions of general and specific methodologies, placing special focus on the interpretation of laboratory findings, and covers the immunology of infectious diseases, including specific pathogens, as well as the full range of autoimmune and immunodeficiency diseases, cancer, and transplantation.<p>Written to guide the laboratory director, the<i>Manual</i> will also appeal to other laboratory scientists, especially those working in clinical immunology laboratories, and pathologists. It is also a useful reference for physicians, mid-level providers, medical students, and allied health students with an interest in the role that immunology plays in the clinical laboratory.</p>


Editorial Board xiContributors xiiiForeword: How it Began xxiiiPreface xxvAuthor and Editor Conflicts of Interest xxviiSection A General Methods 1Volume Editor:Robert G. HamiltonSection Editor:Thomas A. Fleisher1 Introduction 3
Thomas A. Fleisher2 Molecular Methods for Diagnosis of Genetic Diseases Involving the Immune System 5
Amy P. Hsu3 The Human Microbiome and Clinical Immunology 19
Frederic D. Bushman4 Protein Analysis in the Clinical Immunology Laboratory 26
Roshini Sarah Abraham and David R. BarnidgeSection B Immunoglobulin Methods =/ 47Volume Editor:Robert G. HamiltonSection Editor:David F. Keren5 Introduction 49
David F. Keren6 Immunoglobulin Genes 51
Thomas J. Kipps, Emanuela M. Ghia, and Laura Z. Rassenti7 Immunoglobulin Quantification and Viscosity Measurement 65
Jeffrey S. Warren8 Clinical Indications and Applications of Serum and Urine Protein Electrophoresis 74
David F. Keren and Richard L. Humphrey9 Immunochemical Characterization of Immunoglobulins in Serum, Urine, and Cerebrospinal Fluid 89
Elizabeth Sykes and Yvonne Posey10 Cryoglobulins, Cryofibrinogenemia, and Pyroglobulins 101
Peter D. Gorevic and Dennis Galanakis11 Strategy for Detecting and Following Monoclonal Gammopathies 112
Jerry A. Katzmann and David F. KerenSection C Complement 125Volume Editor:Robert G. HamiltonSection Editor:Patricia C. Giclas12 Introduction 127
Patricia C. Giclas13 The Classical Pathway of Complement 129
Patricia C. Giclas14 Analysis of Activity of Mannan-Binding Lectin, an Initiator of the Lectin Pathway of the Complement System 133
Steffen Thiel15 The Nature of the Diseases That Arise from Improper Regulation of the Alternative Pathway of Complement 138
Richard J. H. SmithSection D Flow Cytometry 145Volume Editor:John L. SchmitzSection Editor:Maurice R. G. Ogorman16 Introduction 147
Maurice R. G. Ogorman17 Polychromatic Flow Cytometry 149
Angélique Biancotto andJ. Philip Mccoy, Jr.18 High-Sensitivity Detection of Red and White Blood Cells in Paroxysmal Nocturnal Hemoglobinuria by Multiparameter Flow Cytometry 168
Andrea Illingworth, Michael Keeney, and D. Robert Sutherland19 Standardized Flow Cytometry Assays for Enumerating CD34+ Hematopoietic Stem Cells 182
D. Robert Sutherland and Michael Keeney20 Functional Flow Cytometry-Based Assays of Myeloid and Lymphoid Functions for the Diagnostic Screening of Primary Immunodeficiency Diseases 199
Maurice R. G. Ogorman21 Acute Lymphoblastic Leukemia/Lymphoma: Diagnosis and Minimal Residual Disease Detection by Flow Cytometric Immunophenotyping 207
Joseph A. Digiuseppe22 Acute Myeloid Leukemia: Diagnosis and Minimal Residual Disease Detection by Flow Cytometry 217
Brent Wood and Lori Soma23 Chronic Lymphocytic Leukemia, the Prototypic Chronic Leukemia for Flow Cytometric Analysis 226
Heba Degheidy, Dalia A. A. Salem, Constance M. Yuan, and Maryalice Stetler-Stevenson24 Plasma Cell Disorders 235
Juan Flores-Montero, Luzalba Sanoja, José Juan Pérez, Fanny Pojero, Noemí Puig, MaríaBelén Vidriales, and Alberto Orfao25 Future Cytometric Technologies and Applications 251
Holden T. MaeckerSection E Functional Cellular Assays 259Volume Editor:Barbara DetrickSection Editor:Steven D. Douglas26 Introduction 261
Steven D. Douglas27 Cryopreservation of Peripheral Blood Mononuclear Cells 263
Adriana Weinberg28 Lymphocyte Activation 269
Roshini Sarah Abraham29 Functional Assays for B Cells and Antibodies 280
Moon H. Nahm and Robert L. Burton30 Methods for Detection of Antigen-Specific T Cells by Enzyme-Linked Immunospot Assay (ELISPOT) 290
Barbara L. Shacklett and Douglas F. Nixon31 Regulatory T Cell (Treg) Assays: Repertoire, Functions, and Clinical Importance of Human Treg 296
Theresa L. Whiteside32 Measurement of NK Cell Phenotype and Activity in Humans 300
Samuel C. C. Chiang and Yenan T. Bryceson33 Functional Assays for the Diagnosis of Chronic Granulomatous Disease 310
Debra Long Priel and Douglas B. KuhnsSection F Cytokines and Chemokines 321Volume Editor:Barbara DetrickSection Editor:John J. Hooks34 Introduction 323
John J. Hooks35 Multiplex Cytokine Assays 324
Elizabeth R. Duffy and Daniel G. Remick36 Cytokine Measurement by Flow Cytometry 338
Holden T. Maecker37 Chemokine and Chemokine Receptor Analysis 343
Sabina A. Islam, Benjamin D. Medoff, and Andrew D. Luster38 Cytokines: Diagnostic and Clinical Applications 357
Priyanka Vashisht and Timothy B. Niewold39 Detection of Anticytokine Autoantibodies and Clinical Applications 365
S Arah K. BrowneSection G Immunohistology and Immunopathology 373Volume Editor:Robert G. HamiltonSection Editor:R. Neal Smith40 Introduction 375
Robert G. Hamilton41 Immunofluorescence Methods in the Diagnosis of Renal and Cardiac Diseases 376
A. Bernard Collins, James R. Stone, and R. Neal Smith42 Western Blot Analysis for the Detection of Anti-Glomerular Basement Membrane Antibodies and Anti-Phospholipase A2 Receptor Antibodies 385
A. Bernard Collins and R. Neal SmithSection H Infectious Diseases Caused by Bacteria, Mycoplasmas, Chlamydiae, and Rickettsiae 391Volume Editor:John L. SchmitzSection Editor:Christine M. Litwin43 Introduction 393
Christine M. Litwin44 Diagnostic Methods for Group A Streptococcal Infections 394
Christine M. Litwin, Sheldon E. Litwin, and Harry R. Hill45 Diagnosis of Helicobacter pylori Infection andAssessment of Eradication 404
Bruce E. Dunn and Suhas H. Phadnis46 Laboratory Diagnosis of Syphilis 412
John L. Schmitz47 Lyme Disease, Relapsing Fever, and Leptospirosis 419
Guiqing Wang and Maria E. Aguero-Rosenfeld48 Immunological Tests in Tuberculosis 433
Christine M. Litwin49 Mycoplasma: Immunologic and Molecular Diagnostic Methods 444
Ken B. Waites, Mary B. Brown, and Jerry W. Simecka50 Chlamydia and Chlamydophila Infections 453
Rosemary She51 The Rickettsiaceae, Anaplasmataceae, and Coxiellaceae 461
Lucas S. Blanton and David H. Walker52 The Bartonellaceae, Brucellaceae, and Francisellaceae 473
Christine M. Litwin, Burt Anderson, Renee Tsolis, and Amy RasleySection I Mycotic and Parasitic Diseases 483Volume Editor:Robert G. HamiltonSection Editor:Thomas B. Nutman53 Introduction 485
Thomas B. Nutman54 Immunological and Molecular Approaches for the Diagnosis of Parasitic Infections 486
Patricia P. Wilkins and Thomas B. Nutman55 Serological and Molecular Diagnosis of Fungal Infections 503
Mark D. LindsleySection J Viral Diseases 535Volume Editor:John L. SchmitzSection Editors:Richard L. Hodinka and John L. Schmitz56 Introduction 537
John L. Schmitz57 Immunologic and Molecular Methods for Viral Diagnosis 538
Marie Louise Landry and Yi-Wei Tang58 Herpes Simplex Virus 550
D. Scott Schmid59 Varicella-Zoster Virus 556
D. Scott Schmid60 Epstein-Barr Virus and Cytomegalovirus 563
Henry H. Balfour, Jr., Kristin A. Hogquist, and Priya S. Verghese61 Human Herpesviruses 6, 7, and 8 578
Richard L. Hodinka62 Parvovirus B19 591
Stanley J. Naides63 Respiratory Viruses 598
David J. Speicher, Mohsin Ali, and Marek Smieja64 Measles, Mumps, and Rubella Viruses 610
Diane S. Leland and Ryan F. Relich65 Viral Hepatitis 620
Hubert G. M. Niesters, Annelies Riezebos-Brilman, and Coretta C. Van Leer-Buter66 Viral Agents of Gastroenteritis 639
Gabriel I. Parra and Kim Y. Green67 Arboviruses 648
Robert S. Lanciotti and John T. Roehrig68 Diagnosis of Hantavirus Infections 658
William Marciel De Souza and Luiz Tadeu Moraes Figuereido69 Rabies Virus 665
D. Craig Hooper70 Human T-Cell Lymphotropic Virus Types 1 and 2 674
Breanna Caruso, Raya Massoud, and Steven Jacobson71 Diagnosis of Prion Diseases 682
Richard Rubenstein, Robert B. Petersen, and Thomas Wisniewski72 Principles and Procedures of Human Immunodeficiency Virus Diagnosis 696
Kelly A. Curtis, Jeffrey A. Johnson, and S. Michele OwenSection K Immunodeficiency Diseases 711Volume Editor:Barbara DetrickSection Editors:Kathleen E. Sullivan and Howard M. Lederman73 The Primary Immunodeficiency Diseases 713
Howard M. Lederman74 Severe Combined Immune Deficiency: Newborn Screening 715
James W. Verbsky and John M. Routes75 Combined Immunodeficiencies 721
Christine Seroogy and Melissa Elder76 Antibody Deficiencies 737
Kimberly C. Gilmour, Anita Chandra, and D. S. Kumararatne77 Hereditary and Acquired Complement Deficiencies 749
Patricia C. Giclas78 Neutropenia and Neutrophil Defects 765
Steven M. Holland79 Evaluation of Natural Killer (NK) Cell Defects 774
Kimberly Risma and Rebecca MarshSection L Allergic Diseases 781Volume Editor:Robert G. HamiltonSection Editor:Pamela A. Guerrerio80 Introduction 783
Pamela A. Guerrerio81 Quantitation and Standardization of Allergens 784
Ronald L. Rabin, Lynnsey Renn, and Jay E. Slater82 Immunological Methods in the Diagnostic Allergy Clinical and Research Laboratory 795
Robert G. Hamilton83 Assay Methods for Measurement of Mediators and Markers of Allergic Inflammation 801
John T. Schroeder, R. Stokes Peebles, Jr., and Pamela A. Guerrerio84 Tests for Immunological Reactions to Foods 815
Carah B. Santos, David M. Fleischer, and Robert A. Wood85 Diagnosis of Rare Eosinophilic and Mast Cell Disorders 825
Cem Akin, Calman Prussin, and Amy D. KlionSection M Systemic Autoimmune Diseases 839Volume Editor:Barbara DetrickSection Editor:Westley H. Reeves86 Introduction 841
Westley H. Reeves87 Antinuclear Antibody Tests 843
Alessandra Dellavance, Wilson De Melo Cruvinel, Paulo Luiz CarvalhoFrancescantonio, and Luis Eduardo Coelho Andrade88 Detection of Autoantibodies by Enzyme-Linked Immunosorbent Assay and Bead Assays 859
Edward K. L. Chan, Rufus W. Burlingame, and Marvin J. Fritzler89 Immunodiagnosis and Laboratory Assessment of Systemic Lupus Erythematosus 868
Westley Reeves, Shuhong Han, John Massini, and Yi Li90 Immunodiagnosis of Autoimmune Myopathies 878
Minoru Satoh, Angela Ceribelli, Michito Hirakata, and Edward K. L. Chan91 Immunodiagnosis of Scleroderma 888
Masataka Kuwana92 Antibody and Biomarker Testing in Rheumatoid Arthritis 897
Ann Duskin Chauffe and Michael Raymond Bubb93 Antiphospholipid Antibody Syndrome: Clinical Manifestations and Laboratory Diagnosis 905
Martina Murphy and Neil Harris94 Antineutrophil Cytoplasmic Antibodies (ANCA) and Strategies for Diagnosing ANCA-Associated Vasculitides 909
R. W. Burlingame, C. E. Buchner, J. G. Hanly, and N. M. Walsh95 IgG4-Related Disease: Diagnostic Testing by Serology, Flow Cytometry, and Immunohistopathology 917
John H. Stone96 Future Perspectives for Rheumatoid Arthritis and Other Autoimmune Diseases 922
Jeremy SokoloveSection N Organ-localized Autoimmune Diseases 927Volume Editor:John L. SchmitzSection Editors:C. Lynne Burek and Patrizio Caturegli97 Introduction 929
C. Lynne Burek98 Endocrinopathies: Chronic Thyroiditis, Addison Disease, Pernicious Anemia, Graves Disease, Diabetes, and Hypophysitis 930
C. Lynne Burek, N. R. Rose, Giuseppe Barbesino, Jian Wang, Andrea K. Steck, George S. Eisenbarth, Liping Yu, Ludovica De Vincentiis, Adriana Ricciuti, Alessandra De Remigis, and Patrizio Caturegli99 Myasthenia Gravis 954
Arnold I. Levinson and Robert P. Lisak100 Autoantibodies to Glycolipids in Peripheral Neuropathy 961
Hugh J. Willison101 Detection of Antimitochondrial Autoantibodies in Primary Biliary Cholangitis and Liver Kidney Microsomal Antibodies in Autoimmune Hepatitis 966
Patrick S. C. Leung, Michael P. Manns, Ross L. Coppel, and M. Eric Gershwin102 Cardiovascular Diseases 975
Cheryl L. Maier, C. Lynne Burek, Noel R. Rose, and Aftab A. Ansari103 Celiac Disease and Inflammatory Bowel Disease 983
Melissa R. Snyder104 Autoantibodies Directed against Erythrocytes in Autoimmune Hemolytic Anemia 990
R. Sue Shirey and Karen E. King105 Immune Thrombocytopenia 995
Thomas S. Kickler106 Monitoring Autoimmune Reactivity within the Retina 998
John J. Hooks, Chi-Chao Chan, H. Nida Sen, Robert Nussenblatt, and Barbara DetrickSection O Cancer 1005Volume Editor:Robert G. HamiltonSection Editors:Daniel Chan and Lori J. Sokoll107 Introduction 1007
Robert G. Hamilton108 Immunoassay-Based Tumor Marker Measurement: Assays, Applications, and Algorithms 1008
Elizabeth A. Godbey, Lori J. Sokoll, and Alex J. Rai109 Malignancies of the Immune System: Use of Immunologic and Molecular Tumor Markers in Classification and Diagnostics 1015
Elaine S. Jaffe and Mark Raffeld110 Monitoring of Immunologic Therapies 1036
Theresa L. Whiteside111 Circulating Tumor Cells as an Analytical Tool in the Management of Patients with Cancer 1051
Daniel C. Danila, Howard I. Scher, and Martin FleisherSection P Transplantation Immunology 1063Volume Editor:Barbara DetrickSection Editors:Elaine F. Reed and Qiuheng Jennifer Zhang112 Histocompatibility and Immunogenetics Testing in the 21st Century 1065
Qiuheng Jennifer Zhang and Elaine F. Reed113 Molecular Methods for Human Leukocyte Antigen Typing: Current Practices and Future Directions 1069
Mark Kunkel, Jamie Duke, Deborah Ferriola, Curt Lind, and Dimitri Monos114 Evaluation of the Humoral Response in Transplantation 1091
Paul Sikorski, Renato Vega, Donna P. Lucas, and Andrea A. Zachary115 Non-Human Leukocyte Antigen Antibodies in Organ Transplantation 1103
Annette M. Jackson and Bethany L. Dale116 Evaluation of the Cellular Immune Response in Transplantation 1108
Diana Metes, Nancy L. Reinsmoen, and Adriana Zeevi117 Complement in Transplant Rejection 1123
Carmela D. Tan, E. Rene Rodriguez, and William M. Baldwin Iii118 Molecular Characterization of Rejection in Solid Organ Transplantation 1132
Darshana Dadhania, Tara K. Sigdel, Thangamani Muthukumar, Choli Hartono, Minnie M. Sarwal, and Manikkam Suthanthiran119 Killer Cell Immunoglobulin-Like Receptors in Clinical Transplantation 1150
Raja Rajalingam, Sarah Cooley, and Jeroen Van Bergen120 Chimerism Testing 1161
Lee Ann Baxter-LoweSection Q Laboratory Management 1169Volume Editor:Robert G. HamiltonSection Editor:Ronald J. Harbeck121 Clinical Immunology Laboratory Accreditation, Licensure, and Credentials 1171
Linda Cook and Ronald J. Harbeck122 Validation and Quality Control: General Principles and Application to the Clinical Immunology Laboratory 1180
Vijaya Knight and Terri LeboAuthor Index 1193Subject Index 1195

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